Past Funded Projects—Archive

Eric Ackerman (former PNNL)

Effects of Low Doses of Radiation DNA Repair (This project is jointly funded by NASA and DOE)

Bruce N. Ames
University of California, Berkeley, CA

Comparison of Low Dose Radiation, Endogenous Oxidants, and Micronutrient Deficiencies through Analyses of DNA Damage and Cellular Responses

Allan Balmain
University of California, San Francisco, CA

• Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene
• Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis
• An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Mary Helen Barcellos-Hoff and jointly funded by NASA and DOE)

Janet Baulch
University of California, Davis, CA

Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation

Mina Bissell
Lawrence Berkeley National Laboratory, Berkeley, CA

Interaction of Genome and Cellular Microenvironment

Kerry Bloom

The Dynamic Behavior of Broken Chromosomes in Yeast

Kenneth T. Bogen
Lawrence Livermore National Laboratory, Livermore, CA

DNA Damage vs. Cell Killing by Low-Dose Rate Gamma Radiation Ultra Sensitive Measures and Implications for Mechanistically Modeled Cancer Risk

Douglas Boreham
McMaster University, Hamilton, Ontario, Canada

The Adaptive Response in p53 Cancer-prone Mice: Loss of Heterozygosity and Chromosome Instability

Leslie A. Braby
Texas A & M University, College Station, TX

• The Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation

David Brenner
Center for Radiological Research, Columbia University, NY

MFISH Measurements of Chromosomal Aberrations in Individual Exposed in Utero to Gamma-Ray Doses from 5 to 20 cGy

• Is Increased Low-Dose Radiosenstivity Associated with Increased Transgenerational Germline Mutuation Radiosensitivity?
• Significance of the Bystander Effect: Modeling, Experiments, and More Modeling
• The Risk of Cancer Induction Due to Routine Mammographic Screening

Tony Brooks
Washington State University Tri-Cities, Richland, WA

Optimizing the Scientific, Regulatory and Societal Impact of the DOE Low Dose Radiation Research Program

Judith Campisi
Lawrence Berkeley National Laboratory, Berkeley, CA

Cellular and Molecular Studies of Radio-Adaptive Responses

Aloke Chatterjee
Lawrence Berkeley National Laboratory, Berkeley, CA

• Mechanistic Modeling of Bystander Effects: An Integrated Theoretical and Experimental Approach
• Biological Effects of Low-Dose and Low-Dose Rate Radiation Exposures: An Integrated Theoretical and Experimental Approach

David Chen
Lawrence Berkeley National Laboratory, Berkeley, CA

• Low Dose Radiation Induced Proteomic Responses in Mammalian Cells
• Genome-Wide Expression of LLIR and the Biological Consequences

Matthew Coleman
Lawrence Livermore National Laboratory, Livermore, CA

Genome-Scale Modeling of Low Dose Irradiation Responses Using Micro Array Based Gene Networks

Rory Conolly
Society of Toxicology 2009 Award Winners
Chemical Institute for Industrial Toxicology
Research Triangle Park, NC

Use of Computational Modeling to Evaluate Hypotheses About the Molecular and Cellular Mechanisms of Bystander Effects

Douglas Crawford-Brown
University of North Carolina, Chapel Hill, NC

Use of a State-Vector Model of Radiation Carcinogenesis to Integrate Information from In vitro, In vivo, Epidemiological and Physiological Studies

Michael Dupuis
Pacific Northwest National Laboratory, Richland, WA

Molecular Energetics of Clustered Damage Sites

Helen Evans
Case Western Reserve University

Genomic Instability Induced by Low Dose Radiation

James Flynn

Understanding the Issues in Communicating about Low Dose Radiation Exposure

Melvyn Folkard
Gray Cancer Institute, West Palm Beach, FL

A Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced BystanderEffect

John R. Ford
Texas A & M University, College Station, TX

Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs (This project is jointly funded by NASA and DOE)

Albert J. Fornace Jr.
National Cancer Institute, National Institutes of Health, Washington, D.C.

A Functional Genomics Approach Using Radiation-Induced Changes in Gene Expression to Study Low Dose Radiation Effects In Vitro and In Vivo

John Game
Lawrence Berkeley National Laboratory, Berkeley, CA

Monitoring Radiation-Induced Single Strand Breaks in DNA and their Repair

Robert Goble
Clark University, Worcester, MA

Tales from the Crypt: Hierarchical Modeling of Genomic Defense Mechanisms Related to Radiation-Induced Cancers

Edwin H. Goodwin
Los Alamos National Laboratory, Los Alamos, NM

• Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment
• Biological Effects of Low level Ionizing Radiation and Normal Oxidative Damage: The Same or Different?

William Griffith
University of Washington, Seattle, WA

Multi-level Kinetic and Dynamic Biologically Based Risk Models for Low Dose Radiation

James Haber
Brandeis University, Boston, MA

Genetic Control of Repair and Adaptive Responses to Low-level DNA Damage

Eric Hall
Center for Radiological Research, Columbia University, NY

• Individual Genetic Susceptibility (This project is jointly funded by NASA and DOE)
• Mechanisms of the Bystander Effects (This project is jointly funded by NASA and DOE)

William Hazelton
Fred Hutchinson Cancer Institute, Seattle, WA

Biologically-Based Multistage Modeling of Radiation Effects

David G. Hoel

Models of Radiation Induced Translocations Applied to Human Leukemia Risk Estimation

Hoi-Ying Holman
Lawrence Berkeley National Laboratory, Berkeley, CA

High-Resolution Infrared Spectromicroscopy for Molecular Characterization and Imaging of Bystander Effects in Real Time

Michael C. Joiner
Department of Radiation Oncology, Wayne State University, Detroit, MI

Lack of DNA-Damage Mediated ATM Activiation Determines Low-Dose Hyper-Radiosensitivity

Peter J. Johnston
Gray Cancer Institute, West Palm Beach, FL

Mechanisms of Enhanced Cell Killing at Low Doses: Application for Radiation Risk

Gregory A. Kimmel
Pacific Northwest National Laboratory, Richland, WA

A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation

Amy Kronenberg
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA

A Quantitative Assessment of Bystander Mutagenesis in the Mouse Mammary Gland In Vivo

Bruce E. Lehnert
Los Alamos National Laboratory, Los Alamos, NM

Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment

Chaun-Yuan Li
Radiation Biology Research, Duke University Medical Center, Durham, NC

Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing

Jian Jian Li
School of Health Sciences, Purdue University, West Layfayette, IN

Regulation of NF-kB and Mn SOD in Low Dose Radiatoin Induced Adaptive Responses in Mouse and Human Skin Cells

Howard Liber
Colorado State University, Fort Collins, CO

Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells

Charles Limoli
Radiation Biology, University of California, Irvine, CA

Low dose radiation effects of multipotent neural stem and progenitor cells

Barry Michael
Gray Laboratory Cancer Research Trust
Mount Vernon Hospital, Northwood, Middlesex, United Kingdom

Low-Dose Studies with Focused X-rays in Cell and Tissue Models: Mechanisms of Bystander and Genomic Instability Responses

John Minna
University of Texas, Southwestern Medical Center, Dallas, TX

Human Lung Cancer Progression Model for HZE Particle Exposure
(This NSCOR project is jointly funded by NASA and DOE)

Harvey Mohrenweiser

DNA Repair Gene Variants: Understanding Mechanisms of Cellular Response and Estimating Individual Health Risk from Low-Dose Radiation Exposure

Suresh H. Moolgavkar
University of Washington, Seattle, WA

Stochastic Models for Low LET Radiation Risk Estimation at Low Dose and Dose Rate

Alec Moreley

Development of PCR Based Methods for the Detection of Mutagenic Effects of Ionizing Radiation

James E. Morris

• Sensitivity to Radiation-Induced Cancer in Hemachromatosis
• Real-Time Molecular Study of Bystander Effect Using Living Cell Imaging and Nanaparticles Optics
• Molecular Characterization of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure

Mohan Natarajan
University of Texas Health Science Center, Dallas, TX

Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging

David Nelson
Lawrence Livermore National Laboratory, Livermore, CA

Methods for Deriving Gene and Pathway Specific Dose Response Curves from Expression Experiments Using DNA Microarrays

Lee Opresko
Pacific Northwest National Laboratory, Richland, WA

Mechanisms(s) of Three-Dimensional Intercellular Signaling in Mammary Epithelial Cells in Response to Low Dose, Low-LET Radiation: Implications for the Radiation-Induced Bystander Effects

Thom Orlando

A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation

Louise Prakash
University of Texas, Galveston, TX

Repair of DNA Damage Induced by Ionizing Radiation and Other Oxidative Agents in Yeast and Human

Kevin Prise
Gray Cancer Institute, West Palm Beach, FL

Bystander and Adaptive Responses in Tissue Models Exposed to Low Radiation Doses

Eugene Rinchik
Oak Ridge National Laboratory, Oak Ridge, TN

Genetic Variation in Tissue Responses to Low-Dose Radiation

Kanokporn Rithidech
University of New York at Stony Brook, Stony Brook, NY

Induction of Genomic Instability In Vivo by Low Doses of 137Cs Gamma Rays

Brenda Rodgers
West Texas A&M University, Canyon, TX

Transcriptional and Radio-Adaptive Responses to Low Dose Rate Environmental Exposures to The Radioactive Fallout at Chornobyl

Rainer Sachs
University of California, Berkeley, CA

• Cytogenetic tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks
• Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability, and Cancer

Jeffrey Saffer

Linking Molecular Events to Cellular Responses at Low Dose Exposures

David Schild
Lawrence Berkeley National Laboratory, Berkeley, CA

Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells

Jeffrey Schwartz
University of Washington, Seattle, WA

Radiation Sensitivity and Cancer Susceptibility

Bobby Scott
Lovelace Biomedical & Environmental Research Institute, Albuquerque, NM

• Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposures
• Biological-Based Modeling of Low Dose Radiation Risks

Richard D. Smith
Pacific Northwest National Laboratory, Richland, WA

Direct Characterization of the Differences Between DNA Damage for Ionizing Radiation and Endogenous Oxidative Processes

Marianne B. Sowa
Pacific Northwest National Laboratory, Richland, WA

Mechanistic Study of Low Dose Radiation Induced Proteolytic Cascades in Human Mammary Tissue Models

Robert D. Stewart
Purdue University, West Lafayette, IN

• Towards Constructing and Testing a Virtual Tissue
• Kinetic Modeling of Damage Repair, Genome Instability, and Neoplastic Transformation

Tuan Vo-Dinh
Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN

Nanoprobes for Imaging Single Cells under Low-Dose Radiation

Larry H. Thompson
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA

Assessing Biological Function of DNA Damage Response Genes (1)

Larry H. Toburen
East Carolina University, Greenville, NC

Modeling the Physics of Damage Cluster Formation in a Cellular Environment

Jim Tucker

Role of the Adaptive Response in Determining Health Risks from In Vivo Exposures to Low Dose of Ionizing Radiation

Katherine Vallis
Princess Margaret Hospital, Toronto, Ontario, Canada

The Characterization of Genetic Responses to Low Dose Radiation Using a Genome-Wide Insertional Mutagensis Approach

Susan S. Wallace
University of Vermont, Burlington, VT

Free Radical DNA Damage Produced Endogenously and by Low Dose Radiation in Human Cells: Quantitation, Consequences, and Repair

John S. Wassom
Oak Ridge National Laboratory, Oak Ridge, TN

Communicating and Assessing the Science of the Low Dose Radiation Research Program

Thomas Weber
Pacific Northwest National Laboratory, Richland, WA

Linking Molecular Events to Cellular Responses at Low Dose Exposures

Michael Weil
University of Texas, MD Anderson Cancer Center, Houston, TX

Murine Models of Radiation Sensitivity

Walter E. Wilson
Washington State University Tri-Cities, Richland, WA

Monte Carlo Track Structure Simulations for Low-LET Selected Cell Radiation Studies

Basil Worgul
Columbia University, NY

Low-LET Radiation Studies on the Protective Bystander Effect in an Organized Tissue

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