Current Projects

Sally Amundson
Center for Radiological Research, Columbia University

Mechanistic and Quantiative Studies of Bystander Response in 3-D Human Tissues for Low Dose Radiation Risk Estimation

Carl W. Anderson
Brookhaven National Laboratories

Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Potential Application to p53 and Low Dose Ionizing Radiation

Edouard Azzam
UMDNJ- New Jersey Medical School

• In Vivo Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication
• Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts
• Cellular Responses to Low Dose/Very high Dose-Rate Ionizing Radiation: the Role of Endogenous Oxidative Metabolism

Adayabalam Balajee
Columbia University

Biological Effects of Low Dose Radiation in 3D

Allan Balmain
University of California, San Francisco, CA

• Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene
• Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis
• An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Mary Helen Barcellos-Hoff and jointly funded by NASA and DOE)

Mary Helen Barcellos-Hoff
New York University

• Integrated Radiation Biology
• An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue
  (This project is in collaboration with Allan Balmain and jointly funded by NASA and DOE)
• Mechanisms of Tissue Response to Low Dose Radiation
• Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation

Joel Bedford
Colorado State University

• Effects of SOD Down-Regulated Induced Adaptive Response and Bystander Effects
• Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability
• Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure

Eleanor Blakely
Lawrence Berkeley National Laboratory

Multi-cellular Crosstalk in Radiation Damage

David A. Boothman
University of Texas, Southwestern Medical Center, Dallas, TX

• The IGF-1/IGF-1R-MAPK-Secretroy Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-inducible Bystander Effect
• Clusterin: A Low Dose IR-Inducible Molecular Switch Between Life and Death

Simon Bouffler
Health Protection Agency, Oxon, UK

Radiation Leukaemogenesis at Low Doses (NSCOR)
(This NSCOR project is jointly funded by NASA and DOE)

» Return to the top

Xian Chen
Los Alamos National Laboratory

Proteomic-Based Mechanistic Investigation of Low-Dose Radiation-Induced Cellular Responses/Effects

Matthew Coleman
Lawrence Livermore National Laboratory

Using Co-Regulation to Understand Low-Dose Ionizing Radiation Responsive Genes and Pathways

Priscilla Cooper
Lawrence Berkeley Laboratory

• Role of p53 and DNA Repair in Radio-Adaptive Response and Low-Dose Hypersensitivity to Carcinogenic DNA Damage
• DNA Damage Responses to Low Dose Ionizing Radiation
• Mechanisms of Low-Dose Inducible DNA Repair and Adaptive Response

Barbara Corbin
Biomedical Research & Countermeasures Projects, NASA

Lung Cancer, Pathogenesis and HZE Particle Exposure

Michael Cornforth
University of Texas Medical Branch

• Heritable Genetic Changes in Cells Recovered from Irradiated 3-D Tissue Constructs
• Cytogenetic Response to Low Doses of Ionizing Radiation (This project is jointly funded by NASA and DOE)

Francis Cucinotta
National Aeronaut & Space Administration

Radiation Sensitivity and Processingof DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE)

» Return to the top

William Dynan
Medical College of Georgia, Georgia Research Alliance

• Biological effects of low dose irradiation of a vertebrate embryo, Japanese medaka (Oryzias latipes), with a high-energy secondary neutron spectrum
• Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo

Bevin P. Engelward
Division of Biological Engineering, MIT, Cambridge MA

• 'Recombomice' - A New Tool for Studying Homologous Recombination In vivo
• Mechanisms of Low Dose Radio Suppression of Genomic Instability (This project is jointly funded by NASA and DOE)

Charles Geard
Columbia University

• Genetic haplo-insufficiency, the adaptive response, genomic instability and linear energy transfer
• Defining a Possible Low LET Bystander Effect

Lois Swirsky Gold
University of California , Berkeley

• Animal Cancer Tests and Human Cancer Risk Assessment: Margin of Exposure
• Risk Communication: A Broad Perspective on Cancer Risks from Low Exposures to Chemicals
• Comparison of Risk Estimates Based on a Variety of Risk Assessment Methodologies

Zelanna Goldberg
Pharmacology & Toxicology, Graduate Program, University of California, Davis

• Genome Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms
• Evaluation of Genomic and Proteomic Responses to Low Dose IR Exposure in Patients Receiving Therapeutic Radiation
• Effects of Low Dose Ionizing Radiation on Gene Expression in Human Subjects Undergoing Radiotherapy

David J. Grdina
Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL.

• Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E
• Inhibition of NFkB DNA binding by helenalin abolishes the induced radioprotective effect by amifostine's active metabolite WR1065 in human microvascular endothelial cells

Lora M. Green
Radiobiology Program, Loma Linda University, Loma Linda CA

• The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation
• Low Dose Gamma Irradiation Potentiates Secondary Exposure to Gamma Rays or Protons in Thyroid Tissue Analogs (This project is jointly funded by NASA and DOE)

Daila S. Gridley
School of Medicine, Department of Microbiology and Molecular Genetics, Loma Linda University

• Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation
• Mechanisms of Low Dose Radiation-Induced T Helper Cell Function
  (This project is jointly funded by NASA and DOE)

Anthony James
United States Transuranium and Uranium Registry, Washington State University

National Radiobiology Archives

Randy L. Jirtle
Duke University Medical Center, Durham, N.C

• Imprinted Genes and Transposons: Epigenomic Targets for Low Dose Radiation Effects (This project is jointly funded by NASA and DOE)
• Environmental Epigenomics and Adult Disease Susceptibility

Munira Kadhim
Radiation and Genome Stability Unit, Medical Research Council, Harwell, UK.

• Mechanisms Underlying Cellular Responses to Low Dose/Low LET Ionizing Radiation in Primary Haematopoietic Cells
• Genomic Instability Induced by a Bystander Signal

Norman Kleiman
Environmental Health Sciences, Columbia University

Low Dose Radiation Cataract

Terumi Kohwi-Shigematsu
Lawrence Berkeley National Laboratory

• The Effect of Low-Dose Ionizing Radiation on Epigenetic Changes in Chromatin
• SATB1 Deficiency Accounts for High Susceptibility to Low Dose Radiation (This project is jointly funded by NASA and DOE)

» Return to the top

John B. Little
Department of Genetics and Complex Disease, Harvard School of Public Health

Response to Radiation Damage: Effect of Low-Dose Alpha Irradiation in Human Cells: The Role of Induced Genes and the Bystander Effect

Brian Marples
Radiation Biology, William Beaumont Hospital Research Institute

The Application of Flow Cytometry to Examine Damage Clearance in Stem Cells from Whole-body Irradiated Mice

John Miller
Washington State University Tri-Cities

• Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation
• Models for the Generation of Bystander Effects by Low Doses of Ionizing Radiation

William Morgan
Pacific Northwest National Laboratory

• Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program
• Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation
• A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells.
• Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation
• Genetic Factors Affecting Susceptibility to Low-Dose Radiation

Peter O'Neill
Radiation and Genome Stability Unit, Medical Research Council

Janice Pluth
Lawerence Berkeley National Laboratory, Life Sciences

Radiation Sensitivity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE)

J. Leslie Redpath
University of California, Irvine

• Molecular Mechanisms of Suppression of Neoplastic Transformation by Low Doses of Low LET Radiation
• Low Dose Suppression of Neoplastic Transformation In vitro
  (This project is jointly funded by NASA and DOE)
• Preliminary evidence for a dose-rate-dependent threshold for low dose suppression of radiation-induced neoplastic transformation in vitro
  (This project is jointly funded by NASA and DOE)
• Mechanisms Underlying the Adaptive Response against Spontaneous Neoplastic Transformation Induced by Low Doses of Low LET Radiation

Collete Sacksteder
Pacific Northwest National Laboratory

Molecular Mechanisms Underlying Cellular Adaptive Response to Low Dose Radiation

Douglas R. Spitz
Free Radical and Radiation Biology Program, Radiation Oncology, University of Iowa, Iowa City, USA

• Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/LET Ionizing Radiation
• Chinese hamster fibroblasts containing mutations in succinate dehydrogenase subunit C (SDHC) demonstrate increased sensitivity to low dose ionizing radiation

David Springer
Pacific Northwest National Laboratory

• Mitochondrial-derived Oxidants and Cellular Responses to Low-Dose/Low-LET Ionizing Radiation
• Regulated Proteolysis and Bystander Effects in Radiation

David Stenoien
Systems Biology, Pacific Northwest National Laboratory

Characterization of Signaling Events Induced by Low-Dose Ionizing Radiation

Betsy Sutherland
Brookhaven National Laboratory

• DNA Damage Cluster Complexity: Repair in Human Skin to Oligonucleotides
• DNA Damage Clusters in Low level Radiation Response of Human Cells (This project is jointly funded by NASA and DOE)

Pamela Sykes
Flinders University of South Australia

• Mechanism of Low Dose Radiation Protection from DNA Damage and Cancer
• The Role of Somatic Intrachromosomal Recombination in Response to Low-Dose x-Radiation Induced Genetic Damage

» Return to the top

Larry H. Thompson
Lawrence Livermore National Laboratory

• Functional Assessment of Human Variation in Processing Clustered DNA Damage
• Assessing Biological Function of DNA Damage Response Genes (2)

Robert Ullrich
Colorado State University

• Radiation Leukemogenesis at Low Dose Rates (NSCOR) (This NSCOR project is jointly funded by NASA and DOE)
• Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis

Brynn Voy
Oak Ridge National Laboratory

• Molecular Pathways that Mediate Genetic Susceptibility to Low Ionizing Radiation
• Genetic Background Significantly Alters the Response to Low Dose Ionizing Radiation In vivo
• Genetic Variation in Tissue Responses to Low-Dose Radiation

Daojing Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation (This project is jointly funded by NASA and DOE)

Ya Wang
Thomas Jefferson University

• Characterization of the Role of Fit in Maintenance of Genomic Integrity Following Low Dose Radiation In vivo and In vitro

Raymond Leon Warters
University of Utah Health Sciences Center

• Characterization of the Role of TP53 Turnover Rates in Low IR Dose Sensitivity
• Post-Translational Modifications of DNA Damage Response Proteins as a Measure of Cellular Response to Low Doses of Ionizing Radiation

Thomas J. Weber
Pacific Northwest National Laboratory

• Cell Transforming Bystander Signals
• A Paracrine signal Mediates The cell Transformation Response to Low Dose Gamma Radiation in JB6 Cells

Gayle Woloshack
Northwestern University Medical School

• Radiation Risk from Chronic Low-Dose Rate Radiation Exposure: The Role of Life-Time Animal Studies- October Workshop
• Adaptive Response Mechanisms After Chronic Whole-body Exposure to Low-LET Radiation
• Radioprotectors and Tumors: Molecular Studies in Mice

Andrew J. Wyrobek
Lawrence Livermore National Laboratory

• Molecular Mechanisms and Celluar Consequences of Low-Dose Exposure to Ionizing Radiation
• Molecular Mechanisms and Cellular Consequences of Low-Dose Exposures to DNA-Damaging Agents

Chin-Rang Yang
Simmons Comprehensive Cancer Center, University of Texas Southwest Branch

Non-Linear Systems Biology Approach to Model and Analyze the Dynamic Responses of Low-Dose Ionizing Radiation

Zhi-min Yuan
University of Texas

Low Dose IR Creates an Oncogenic Microenviroment by Inducing Premature Senescence In Stromal Fibroblasts

John D. Zimbrick
Colorado State University

Transgenerational Effects of Chronic Low-Dose Irradiation in a Medaka Fish Model System
(This project is jointly funded by NASA and DOE)

» Return to the top