Larry H. Thompson

BBR Program, L452 Lawrence Livermore National Lab

Newly Funded Projects

Functional Assessment of Human Variation in Processing Clustered DNA Damage

Currently Funded Projects

Assessing Biological Function of DNA Damage Response Genes (2)

Technical Abstracts

2006 Workshop:
Assessment of Individual Variation in DNA Double-Strand Break Repair Capacity in Human Diploid Fibroblasts
Wilson, P.F., Hinz, J.M., Nham, P.B., Urbin, S.S., Thomas, C.B., Jones, I.M., and Thompson, L.H.

2005 Workshop:
Cooperation Between Homologous Recombination and the Fanconi Anemia Cancer Suppessor Proteins In Minimizing Spontaneous and Radiation-Induced Chromosomal Instability
Thompson, L.H., Hinz, J.M., Tebbs, R.S. and Yamada, N.A.

2003 Workshop:
Assessing Biological Function of DNA-Damage Response Genes
Thompson, L.H., Tebbs, R.S., Hinz, J. and Yamada, N.A.

2001 Workshop:
Assessing Biological Function of DNA-Damage Response Genes.
Thompson, L.H.,, Liu, N., Schild, L.J., Christian, A.T., Wilson III, D.M., Lamerdin, J.E. and Wrischnik, L.A.

1999 Workshop:
Assessing Biological Function of DNA-Damage Response Genes
Thompson, L.H., Wilson III, D.M. and Tucker, J.D.

Molecular Mechanisms and Cellular Consequences of Low-Dose Exposure to DNA Damaging Agents.
Wyrobek, A.J., Tucker, J., Wilson, D., Thompson, L.H., Kegelmeyer, L., Raja, R., and Marchetti, F.

Publications

Nagasawa, H., Wilson, P.E., Chen, D.J., Thompson, L.H., Bedford, J.S., and Little, J.B. (2008). Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. DNA Repair 7(3):515-522.

Hinz, J.M., Nham, P.B., Urbin, S.S., Jones, I.M., and Thompson, L.H. (2007). Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis. Nucleic Acids Research 35(11):3733-3740.

Thompson, L.H., Hinz, J.M., and Nham, P.B. (2006). Disparate hprt mutagenesis associated with defective fanconi anemia and homologous recombination pathways. Environmental and Molecular Mutagenesis 47(6):422.

Hinz, J.M., Nham, P.B., Salazar, E.P., and Thompson, L.H. (2006). The Fanconi anemia pathway limits the severity of mutagenesis. DNA Repair 5:875-884.

Miller, K.A., Hinz, J.M., Yamada, N.A., Thompson, L.H., and Albala, J.S., (2005). Nuclear localization of Rad51B Is independent of Rad51C and BRCA2. Mutagenesis 20(1):57-63.

Hinz, J.M., Tebbs, R.S., Wilson, P.F., Nham, P.B., Saalazar, E.P., Nagasawa, H., Urbin, S.S., Bedford, J.S., and Thompson, L.H. (2006). Repression of mutagenesis by Rad51D-mediated homologous recombination. Nucleic Acids Research 34(5):1358-1368.

Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y.M., Arakawa, H., Buerstedde, J., Enomoto, T., Takeda, S., Thompson, L.H., and Takata, M. (2006). Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. The EMBO Journal 24:418-427.

Wiese, C., Hinz, J.M., Tebbs, R.S., Nham, P.B., Urbin, S.S, Collins, D.W., Thompson, L.H., and Schild, D. (2006). Disparate requirements for the Walker A and B ATPase notifs of human RAD51D in homologous recombination. Nucleic Acids Research 34(9):2833-2843.

Yamamoto, K., Hirano, S., Ishiai, M., Morishima, K., Kitao, H., Namikoshi, K., Kimura, M., Matsushits, N., Arakawa, H., Buerstedde, J., Komatsu, K., Thompson, L.H., and Takata, M. (2006). Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Molecular and Cellular Biology. 25(1):34-43.

Tebbs, R.S., Hinz, J.M., Yamada, N.A., Wilson, J.B., Salazar, E.P., Thomas, C.B., Jones, I.M., Jones, N.J., and Thompson, L.H. (2005). New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant. DNA Repair 4:11-22.

Thompson, L.H., Hinz, J.M., Yamada, N.A., and Jones, N.J. (2005). How Fanconi a nemia proteins promote the four R’s: Replication, Recombination, Repair, and Recovery. Environmental and Molecular Mutagenesis 45: 128-142.

Lamerdin, J.E., Yamada, N.A., George, J.W., Souza, B., Christian, A.T., Jones, N.J., and Thompson. L.H. (2004). Characterization of the hamster FancG/Xrcc9 gene and mutations CHO UV40 and NM3. Mutagenesis 19(3):237-244.

Yamada, N.A, Hinz, J.M., Kopf, V.L., Segalle, K.D., and Thompson, L.H. (2004). XRCC3 ATPase activity is required for normal XRCC3-Rad516 complex dynamics in homologous recombination. The Journal of Biological Chemistry. 279(22):23250-23254.

Rothkamm, K., Krüger, I., Thompson, L.H., and Löbrich, M. (2003). Pathways of DNA double-strand break repair during the Mammalian cell cycle. Molecular and Cellular Biology 23(16):5706-5715.

Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J.E., Buerstedde , J., Tanimoto, M., Harada, M., Thompson, L.H., and Takata, M. (2003). Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Molecular and Cellular Biology 23(15):5421-5430.

Thompson, L. and Schild, D. (2002). Recombinational DNA repair and human disease. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 519(1-2):15-24.

Thompson, L.H. and Schild, D. (2002). Recombinational DNA repair and human disease, Mutation Research 509:49-78.

Liu, N., Schild, D., Thelen, M.P., and Thompson, L.H. (2002). Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. Nucleic Acids Research 30:1009-1015.

Takata, M., Tachiiri, S., Fujimori, A., Thompson, L.H., Miki, Y., Hiraoka, M., Takeda, S., and Yamazoe, M. (2002). Conserved domains in the chicken homologue of BRCA2. Oncogene 21:1130-1134.

Wiese, C., Collins, D.W., Albala, J.S., Thompson, L.H., Kronenberg, A., and Schild, D. (2002). Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. Nucleic Acids Res. 30:1001-1008.

Fujimori, A., Tachiiri, S., Sonoda, E., Dhar, P.K., Hiraoka, M., Takeda, S., Thompson, L.H., and Takata, M. (2001). Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells. The EMBO Journal 20:5513-5520.

Takata, M., Sasaki, M.S., Tachiiri, S., Fukushima, T., Sonoda, E., Schild, D., Thompson, L.H., and Takeda, S. (2001). Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Molecular Cellular Biology 21:2858-2866.

Thompson, L.H. and Schild, D. (2001). Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutatation Research 477:131-153.

Cappelli, E., Degan, P., Thompson, L.H., and Frosina, G. (2000). Efficient repair of 8-Oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D Cells. Biochemistry 39:10408-10412.

Takata, M., Sasaki, M.S., Sonoda, E., Fukushima, T., Morrison, C., Albala, J.S., Swagemakers, S.M., Kanaar, R., Thompson, L.H., and Takeda, S. (2000). The Rad51 paralog Rad51B promotes homologous recombinational repair. Molecular Cellular Biology 20:6476-6482.

Thompson, L.H. and West, M.G. (2000). XRCC1 keeps DNA from getting stranded. Mutatation Research 459:1-18.

Cleaver, J.E., Thompson, L.H., Richardson, A.S., and States, J.C. (1999). A summary of mutations in the UV-sensitive disorders: Xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Human Mutation 14:9-22.

Pierce, A.J., Johnson, R.D., Thompson, L.H., and Jasin, M. (1999). XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes & Devvelopment 13:2633-2638.

Tebbs, R.S., Flannery, M.L., Meneses, J.J., Hartmann, A., Tucker, J.D., Thompson, L.H., Cleaver, J.E., and Pedersen, R.A. (1999). Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Devvelopment Biology 208:513-529.

Thompson, L.H. (1999). Strategies for cloning mammalian DNA repair genes. In: DNA Repair Protocols: Eukaryotic Systems, Methods in Molecular Biology (D. Henderson, Ed.), Humana Press, Totowa, New Jersey, 113:57-85.

Thompson, L.H. and Schild, D. (1999). The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:87-105.

Liu, N., Lamerdin, J.E., Tebbs, R.S., Schild, D., Tucker, J.D., Shen, M.R., Brookman, K.W., Siciliano, M.J., Walter, C.A., Fan, C.A., Narayana, L.S., Zhou, Z.Q., Adamson, A.W., Sorensen, K.J., Chen, D.J., Jones, N.J., and Thompson, L.H. (1998). XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA crosslinks and other damages. Molecular Cell 1:783-793.

Shen, M.R., Zdzienicka, M.Z., Mohrenweiser, H., Thompson, L.H., and Thelen, M.P. (1998). Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair. Nucleic Acids Research 26:1032-1037.

Thompson, L.H. (1998). Chinese hamster cells meet DNA repair: An entirely acceptable affair. Bioessays 20:589-597.

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