Rainer K. Sachs
University of California, Berkeley
Funded Projects
BIO-BASED RISK MODELING 03-20:
Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability and Cancer
Cytogenetic Tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks
Technical Abstracts
2006 Workshop
The Bystander Effect in Normal Human 3-D Tissue: Experiments, Models, and Implications
Brenner, D., Ponnaiya, B., Shuryak, I., Sachs, R., and Geard, D.
Radiation Carcinogenesis Risk as Influenced by Intercellular Interaction
Hahnfeldt, P., Hlatky, L., and Sachs, R.K.
2005 Workshop:
Modelling Intercellular Interactions During Radiation Carcinogenesis
Sachs, R.K., Chan, M., Hlatky, L., and Hahnfeldt, P.
2003 Workshop:
Chromosome Spatial Clustering Uncovered Through Radiogenic Aberrations
Sachs, R.K., Arsuaga, J., Greulich-Bode, K., Vazquez, M., Hahnfeldt, P., Brenner, D.J., and Hlatky, L.
2002 Workshop:
Frequencies of Radiation Induced Chromosome Interchanges and Randomness of Chromosome Territory Locations Relative to One Another
Sachs, R.K., Cornforth, M.N., Greulich-Bode, K.M., Hlatky, L., and Brenner, D.J.
2001 Workshop:
Are Bystander Effects Important at Low Radiation Doses?
Brenner, D.J., Geard, C.R., Hall, E.J., and Sachs, R.K.
Computer Simulations of Chromosome Aberration Data for Human Cells Subjected to Low-LET Radiation: Mechanistic Implications
Sachs, R.K., Cornforth, M., Vazquez, M., Arsuaga, J., Hlatky, L., Geard, C., and Brenner, D.J.
Net Lifetime Risk of Chronic Myeloid Leukemia: Can it Have a "U" Shaped Low Dose Response?
Radivoyevitch, T., Kozubek, S., and Sachs, R.K.
1999 Workshop:
Cytogenetic Tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks
Sachs, R.K., Brenner, D.J., Geard, C., and Hlatky, L.
Publications
Hodgson, D.C., Koh, E.-S., Tran, T.H., Heydarian, M., Tsang, R., Pintilie, M., Xu, T., Huang, L., Sachs, R.K., and Brenner, D.J. (2007). Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma. Cancer 110(11):2576-2586.
Sachs, R.K., Shuryak, I., Brenner, D.J., Fakir, H., Hlatky, L., and Hahnfeldt, P. (2007). Second cancers after fractionated radiotherapy: Stochastic population dynamics effects. Journal of Theoretical Biology 249(3):518-531.
Koh, E.S., Tran, T.H., Heydarian, M., Sachs, R.K., Tsang, R.W., Brenner, D.J., Pintilie, M., Xu, T., Chung, J., Paul, N., and Hodgson, D.C. (2007). A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: Reduction in normal tissue dose and second cancer risk. Radiation Oncology 2(1):11 p.
Ponomarev, A.L., Belli, M., Hahnfeldt, P.J., Hlatky, L., Sachs, R.K., and Cucinotta, F.A. (2007). Subtraction of background damage in PFGE experiments on DNA fragment-size distributions. Radiation Environmental Biophysics 46(2):155-160.
Brenner, D.J. and Sachs, R.K. (2006). Estimating radiation-induced cancer risks at very low doses: Rationale for using a linear no-threshold approach. Radiation and Environmental Biophysics 44:253-256.
Fakir, H., Sachs, R., Sternerlow, B., Hofmann, W.. (2006). Clusters of DNA double-strand breaks induced by different doses of nitrogen ions for various LETs: Experimental measurements and theoretical analyses. Radiation Research 166:917-927.
Ponomarev, A.L., Belli, M., Hahnfeldt, J., P., Hlatky, L., Sachs, R.K., Cucinotta, F.A. (2006). A robust procedure for removing background damage in assays of radiation-induced DNA fragment distribution. Radiation Research 166:908-916.
Plan, Y., Hlatky, L., Hahnfeldt, P., Sachs, R., Loucas, B., and Cornforth, M. (2005). Full-color painting reveals an excess of radiation-induced dicentrics involving homologous chromosomes. International Journal of Radiation Biology 81(8):613-620.
Sachs, R.K. and Brenner, D.J. (2005). Solid tumor risks after high doses of ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America 102(37):13040-13045.
Sachs, R. K., Chan, M., Hlatky, L., and Hahnfeldt, P. (2005). Modeling intercellular interactions during carcinogenesis. Radiation Research 164:324-331.
Vives, S., Loucas, B., Vazquez, M., Brenner, D.J., Sachs, R.K., Hlatky, L., Cornforth, M., and Arsuaga, J. (2005). SCHIP: statistics for chromosome interphase positioning based on interchange data. Application note. Bioinformatics 21(14):3181-3182.
Mestres, M., Caballin, M.R., Schmid, E., Stephan, G., Sachs, R., Barrios, L., and Barquinero, J.F. (2004). Analysis of α-particle induced chromosome aberrations in human lymphocytes, using pan-centomeric and pan-telomeric probes. International Journal of Radiation Biology 80(10):737-744.
Sachs, R.K., Levy, D., Hahnfeldt, P., and Hlatky, L. (2004). Quantitative analysis of radiation-induced chromsome aberrations. Cytogenetic and Genome Research 104:142-148.
Brenner, D.J., Doll, R., Goodhead, D.T., Hall, E.J., Land, C.E., Little, J.B., Lubin, J.H., Preston, D.L., Preston, R.J., Puskin, J.S., Ron, E., Sachs, R.K., Samet, J.M., Setlow, R.B., and Zaider, M. (2003). Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know. Proceedings of the National Academy of Sciences of the United States of America 100(24):13761-13766.
Brenner, D.J. and Sachs, R.K. (2003). Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thought. Health Physics 85(1):103-108.
Sachs, R.K., Arsuaga, J., Vazquez, M., Hlatky, L., and Hahnfeldt, P. (2002). Using graph theory to describe and model chromosome aberrations. Radiation Research 158:556-567.
Hlatky, L., Sachs, R.K., and Cornforth, M.N. (2002). Radiation-induced chromosome aberrations: Insights gained from biophysical modeling. BioEssays 24:714-723.
Radivoyevitch, T., Kozubek, S., and Sachs, R.K. (2002). The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? Radiation Research 157(1):106-109.
Brenner, D.J. and Sachs, R.K. (2002). Do low dose-rate bystander effects influence domestic radon risks? International Journal of Radiation Biology 78:593-604.
Cornforth, M.N., Greulich-Bode, K.M., Loucas, B.D., Arsuaga, J., Vazequz, M., Sachs, R.K., Bruckner, M., Molls, M., Hahnfeldts, P., Hlatky, L., and Brenner, D.J. (2002). Chromosomes are predominantly located randomly with respect to each other in interphase human cells. Journal of Cell Biology 159(2):237-244.
Radivoyevitch, T., Kozubek, S., and Sachs, R.K. (2002). The risk of chronic myeloid leukemia: Can the dose-response curve be U-Shaped? Radiation Research 157(1):106-109.
Brenner, D.J., Little, J.B., and Sachs, R.K. (2001). The bystander effect in radiation oncogenesis: II. A quantitative model. Radiation Research 155(3):402-408.
Costes, S., Sachs, R.K., Hlatky, L., Vannais, D., Waldren, C., and Fouladi, B. (2001). Large-mutation spectra induced at hemizygous loci by low-LET radiation: Evidence for intrachromosomal proximity effects. Radiation Research 156(5 Pt 1):545-557.
Ponomarev, A.L., Cucinotta, F.A., Sachs, R.K., and Brenner, D.J. (2001). Monte Carlo predictions of DNA fragment-sized distributions for large sizes after HZE particle irradiation. Physica Medica 17 Suppl. 1:153-156.
Ponomarev, A.L., Cucinotta, F.A., Sachs, R.K., Brenner, D.J., and Peterson, L.E. (2001). Extrapolation of the DNA fragment-size distributions in a high-dose PFGE assay to low doses. Radiation Research 156(5 Pt 2):594-597.
Ponomarev, A.L. and Sachs, R.K. (2001). Radiation breakage of DNA: A model based on random-walk chromatin structure. Journal of Mathematical Biology 43:356-376.
Radivoyevitch, T., Sachs, R.K., Nikiforov, Y.E., Nikiforova, M.N., and Little, M.P. (2001). On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer. Radiation and Environmental Biophysics 40:191-197.
Radivoyevitch, T., Kozubek, S., and Sachs, R.K. (2001). Biologically-based risk estimation for radiation-induced CML: Inferences from BCR and ABL geometric distributions. Radiation and Environmental Biophysics 40:1-9.
Brenner, D.J. and Sachs, R.K. (2000). Protraction effects in radiation studies: I. Basic biophysics. Extended abstract. Radiation Research 154(6):736-737.
Sachs, R.K., Levy, D., Chen, A.M., Simpson, P.J., Cornforth, M.N., Ingerman, E.A., Hahnfeldt, P., and Hlatky, L.R. (2000). Random breakage and reunion chromosome aberration formation model: An interaction distance version based on chromatin geometry. International Journal of Radiation Biology 76(12):1579-1588.
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