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Mohan Natarajan

University of Texas Health Science Center

Glue Grant

Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging

About the Project

Molecular Characterization of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure

Funded Project

Real-Time Molecular Study of Bystander Effect Using Living Cell Imaging and Nanaparticles Optics, abstract, description.

Technical Abstracts

2006 Workshops:
SHP-2 Tyrosine Phosphate-Dependent Focal Adhesion Kinase Mediated Cell Migration of Primary Endothelial Cells Upon Low LET Radiation Exposure
Zheng, X., Mohan, S., and Natarajan, M.

Tumor Cell-Mediated Bystander Response on the Angiogenic Potentials of Endothelium
Natarajan, M., Bo, Y., Mohan, S., and Otto, R.A.

2005 Workshops:
Role of TNF-α as a Potential Signaling Mediator of Radiation-Induced Bystander Effect in Human Vascular Cells
Natarajan, M., Mohan, S., Gibbons, C., Bo, Y., and Kadhim, M.A.

Real-Time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging
Nallathamby, P.D., Xu, X.N., and Natarajan, M.

2003 Workshop:
Occurrence of a Positive Feed Back Loop Between TNF-a and NF-KB in Aortic Endothelial Cells Upon Exposure to Low Dose-Low LET Radiation
Natarajan M., Mohan S., Pandeswara S.L., and Roldan F.A.

Oxidative Stress Signaling is Responsible for TNF-a Induced Genetic Damage in Primary Human Aortic Endothelial Cells
Natarajan M., Kadhim M.A., Mohan S., Stephen R.M., and Pandeswara, S.L.

Radiation-Induced Nuclear Factor kB Mediates Survival Advantage by Telomerase Activation.
Natarajan M., Mohan S., Pandeswara, S.L., and Herman T.S.

Publications

Natarajan, A.T., Berni, A., Marimuthu, K.M., and Palitti, F. (2008). The type and yield of ionizing radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells. Mutation Research 642(1-2):80-85.

Aravindan, N., Madhusoodhanan, R., Natarajan, M., and Herman, T.S. (2008). Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells. Molecular and Cellular Biochemistry 310(1-2):167-179.

Natarajan, M., Gibbons, C.F., Mohan, S., Moore, S., and Kadhim, M.A. (2007). Oxidative stress signalling: A potential mediator of tumour necrosis factor alpha-induced genomic instability in primary vascular endothelial cells. British Journal of Radiology 80(Sp. Iss.):S13-S22.

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