Barry D. Michael

Gray Laboratory Cancer Research Trust
Mount Vernon Hospital
Northwood, Middlesex HA6 2JR,United Kingdom

Past Project

Low dose Studies with focused x-rays in cell and tissue models: Mechanisms of bystander and genomic instability responses

Publications

Hamada, N., Schettino, G., Kashino, G., Vaid, M., Suzuki, K., Kodama, S., Vojnovic, B., Folkard, M., Watanabe, M., Michael, B.D., and Prise, K.M. (2006). Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft x-rays: Evidence for chromatin movement during repair. Radiation Research 166(1):31-38.

Belyakov, O.V., Folkard, M., Mothersill, C., Prise, K.M. and Michael, B.D. (2006). Bystander-induced differentiation: A major response to targeted irradiation of a urothelial explant model. Mutation Research 597(1-2):43-49.

Prise, K.M., Folkard, M., and Michael, B.D. (2006). Radiation-induced bystander and adaptive responses in cell and tissue options. Dose-Response 4(4):263-276.

Shao, C., Folkard, M., Michael, B.D., and Prise, K.M. (2005). Bystander signaling between glioma cells and fibroblasts targeted with counted particles. International Journal of Cancer 116(1):45-51.

Moore, S.R., Marsden, S., Macdonald, D., Mitchell, S., Folkard, M., Michael, B.D., Goodhead, D.T., Prise, K.M., and Kadhim, M.A. (2005). Genomic instability in human lymphocytes irradiated with individual charged particles: Involvement of tumor necrosis factor α in irradiated cells but not bystander cells. Radiation Research 163:183-190.

Kashino, G., Prise, K.M., Schettino, G., Folkard, M., Vojnovic, B., Michael, B.D., Suzuki, K., Kodama, S., and Watanabe, M. (2004). Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutation Research 556(1-2):209-215.

Shao, C., Folkard, M., Michael, B.D., and Prise, K.M. (2004). Targeted cytoplasmic irradiation induces bystander responses. Proceedings of the National Academy of Sciences of the United States 101(37):13495-13500.

Prise, K.M., Folkard, M., and Michael, B.D. (2004). Radiation-induced bystander and adaptive responses in cell and tissue models, The 14th Pacific Basin Nuclear Conference, Honolulu, Hawaii.

Shao, C., Stewart, V., Folkard, M., Michael, B.D., and Prise, K.M. (2003). Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Research 63:8437-8442.

Prise, K.M., Folkard, M., and Michael, B.D. (2003). Bystander responses induced by low LET radiation. Oncogene 22:7043-7049.

Schettino, G., Folkard, M., Prise, K.M., Vojnovic, B., Held, K.D., and Michael, B.D. (2003). Low-Dose studies of Bystander cell killing with targeted soft x-rays. Radiation Research 160(5):505-511

Prise, K.M., Belyakov, O.V., Folkard, M., Ozols, A., Schettino, G., Vojnovic, B., and Michael, B.D. (2002). Investigating the cellular effects of isolated radiation tracks using microbeam techniques. Advances in Space Research 30(4): 871-876.

Prise, K.M., Belyakov, O.V., Folkard, M., Ozols, A., Schettino, G., Vojnovic, B., and Michael, B.D. (2002). Investigating the cellular effects of isolated radiation tracks using microbeam techniques. Advances in Space Research 30(4):871-876.

Folkard, M., Prise, K.M., Turner, C.J., and Michael, B.D. (2002). The production of single-strand and double-strand breaks in DNA in aqueous solution by VUV photons below 10eV. Radiation Protection Dosimetry 99:147-149

Folkard, M., Vojnovic, B., Prise, K.M., and Michael, B.D. (2002). The application of charge-particle microbeams in radiation biology. Nuclear Instruments and Methods in Physics Research, Section B, Beam Interactions with Materials and Atoms (NIMB) B188:49-54.

Belyalov, O.V., Folkard, M., Mothersill, C., Prise, K.M. and Michael, B.D. (2003). A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. British Journal of Cancer 88:767-774.

Belyakov, O.V., Folkard M., Mothersill, C., Prise, K.M., Michael, B.D. (2002). Bystander-induced Apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiation Protection Dosimetry. 99(1-4):249-251

Belyakov, O.V., Malcolmson, A.M., Folkard, M., Prise, K.M., and Michael, B.D. (2001). Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. British Journal of Cancer 84(5):674-679.

Folkhard, M., Schettino, G., Vojnovic, B., Gilchrist, S., Michette, A.G., Pfauntsch, S.J., Prise K.M., and Michael, B.D. (2001). A focused ultrasoft x-ray microbeam for targeting cells individually with submicrometer accuracy. Radiation Research 156:796-804.

Folkhard, M., Prise, K.M., Vojnovic, B., Gilchrist, S., Schettino, G., Belyakov, O.V., Ozols, A., and Michael, B.D. (2001). The impact of microbeams in radiation biology. Nuclear Instruments and Methods in Physics Research, Section B, Beam Interactions with Materials and Atoms (NIMB) 181(1-4):426-430.

Michael, B.D., Held, K.D., Schettino, G., Folkard, M., Prise, K.M., and Vojnovic, B. (2001). Charged-particle and focused soft x-ray microbeams for investigating individual and collective radiation responses of cells. Radiation Research 156:439-440.

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