Jian Jian Li

School of Health Sciences, Purdue University

Newly Funded Projects

Regulation of NF-kB and Mn SOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description.

Technical Abstracts

2006 Workshops:
NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells
Ahmed, K.M., Fan, M., Spitz, and Li, J.J.

2005 Workshops:
Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1.
Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R.

2003 Workshops:
Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation
Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and Coleman, M.A.

Publications

Cao, N., Li, S.Y., Wang, Z.Q., Ahmed, K.M., Degnan, M.E., Fan, M., Dynlacht, J.R., and Li, J.J. (2009). NF-kappa B-mediated HER2 overexpression in radiation-adaptive resistance. Radiation Research 171(1):9-21.

Ahmed, K.M., Fan, M., Nantajit, D., Cao, N., and Li, J.J. (2008). Cyclin D1 in low-dose radiation-induced adaptive resistance. Oncogene 27(53):6738-6748.

Wang, Z., Cao, N., Nantajit, D., Fan, M., Liu, Y., and Li, J.J. (2008). MKP-1 represses JNK-mediated apoptosis via NF-kappa B regulation. Journal of Biological Chemistry 283(30):21011-21023.

Murley, J.S., Nantajit, D., Baker, K.L., Kataoka, Y., Li, J.J., and Grdina, D.J. (2008). Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiation Research 169(5):495-505.

Ahmed, K.M., and Li, J.J. (2008). NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radical Biology and Medicine 44(1):1-13.

Ahmed, K.M., and Li, J.J. (2007). ATM-NF-kappa B connection as a target for tumor radiosensitization. Current Cancer Drug Targets 7(4):335-342.

Ahmed, K.M., Dong, S.Z., Fan, M., and Li, J.J. (2006). Nuclear factor-kappa B p65 inhibits mitogen-activated protein kinase signaling pathway in radio-resistant breast cancer cells. Molecular Cancer Research 4(12):945-955.

Zhou, J.Q., Lim, C.U.K., Li, J.J., Cai, L., and Zhang, Y. (2006). The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer Letters 243(1):9-15.

Ahmed, K.M., Cao, N., and Li, J.J. (2006). HER-2 and NF-kappa B as the targets for therapy-resistant breast cancer. Anticancer Research 26(6B):4235-4243.

Wang, T.L., Tamae, D., LeBon, T., Shively, J.E., Yen, Y., and Li, J.J. (2005). The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. Cancer Research 65(22):10338-10346.

Liu, L., Zhang, J., Bates, S., Li, J.J., Rhim, J.S., and Pfeifer, G.P. (2005). A methylation profile of in vitro immortalization human cell lines. International Journal of Oncology 26:275-285.

Wang, T., Hu, Y.C., Dong, S.Z., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, J.J. (2005). Co-activation of ERK, NF-κB and GADD45β in response to ionizing radiation. Journal of Biological Chemistry 280(13):12593-12601.

Murley, J., Kataoka, Y., Cao, D., Li, J.J., Oberley, L.W., and Grdina, D.J. (2004). Delayed radioprotection via NF- k B mediated induction of Sod2 (MnSOD) in SA-NH tumor cells following exposure to clinically used thiol containing drugs. Radiation Research 162:536-546.

Ozeki, M., Tamea, D., Hou, D.X., Wang, T., LeBon, T., Spitz, D.R., and Li, J.J. (2004). Response of cyclin B1 to ionizing radiation: Regulation by NF- k B and mitochondrial antioxidant enzyme MnSOD. Anticancer Research 24:2657-2663.

Gou, G., Wang, T., Gao, Q., Tamae, D., Wong, P., Chen, T., Chen, W.-C., Shively, J.E., Wong, J.Y.C., and Li, J.J. (2004). Expression of ErbB2 enhances radiation-induced NF-κB activation. Oncogene 23:535-545.

Spitz, D.R., Azzam, E.I., Li, J.J., and Gius, D. (2004). Metabolic oxidation/reduction reactions and cellular responses to radiation: A unifying concept in stress response biology. Cancer and Metastasis Reviews 23:311-322.

Xia, L., Paik, A., and Li, J.J. (2004). p53 Activation in chronic radiation-treated breast cancer cells. Regulation of MDM2/p14ARF. Cancer Research 64(1):221-228.

Guo, G., Yan-Sanders, Y., Lyn-Cook, B.D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z., Weydert, C., Longmate, J.A., Huang, T.-T., Spitz, D.R., Oberley, L.W., and Li, J.J. (2003). Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Molecular and Cellular Biology 23:2362-2378.

Wang, T., Zhang, X., and Li, J.J. (2002). The role of NFKB in the regulation of cell stress responses. International Immunopharmacology 2(11):1509-1520.

Xufeng, C., Shen, B., Xia, L., Khaletzkiy, A., Chu, D., Wong, J.Y.C., and Li, J.J. (2002). Activation of nuclear factor KB in radioresistance of TP53-inactive human keratinocytes. Cancer Research 62(4):1213-1221.

Yu, C.-Y., Wang, L., Khaletskiy, A., Farrar, W.L., Larner, A., Colburn, N.H., and Li, J.J. (2002). STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells. Oncogene 21:39-49-3960.

Chen, X., Shen, B., Xia, L., Khaletzkiy, A., Chu, D., Wong, J.Y.C., and Li, J.J. (2002). Activation of nuclear factor kB in radioresistance of TP53-inactive human keratinocytes. Cancer Research 62:1213-1221.

Li, Z., Xia, L., Lee, L.M., Khaletskiy, A., Wang, J., Wong, J.Y.C., and Li, J.J. (2001). Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiation. Radiation Research 155:543-553.

Li, Z., Khaletskiy, A., Wang, J., Wong, J.Y.C., Oberley, L.W., and Li, J.J. (2001). Genes regulated in human breast cancer cells overexpressing manganese-containing superoxide dismutase. Free Radical Biology & Medicine 30(3):260-267.

Li, J.J., Cao, Y., Young, M.R., and Colburn, N.H. (2000). Induced expression of dominant-negative c-jun downregulates NFKB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes. Molecular Carcinogenesis 29:159-169.

Ding, M., Li, J.J., Leonard, S.S., Ye, J-P, Shi, X., Colburn, N.H., Castranova, V., and Vallyathan, V. (1999). Vanadate-induced activiation of activator protein-1: Role of reactive oxygen species. Carcinogenesis 20(4):663-668.

Li, J.J., Rhim, J.S., Schlegel, R., Vousde, K.H., and Colburn, N.H. (1998). Expression of dominant negative Jun inhibits elevated AP-1 and NFKB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes. Oncogene 16(21):2711-2721.

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