Michael N. Cornforth
University of Texas, Medical Branch
Currently Funded Projects
Cytogenetic Response to Low Doses of Ionizing Radiation
Technical Abstracts
2006 Workshop:
Chromosome Rearrangements in the Clonal Descendants of hTERT-Immortalized Human Cells Exposed to Gamma Rays.
Eberle, R., Loucas, B, and Cornforth, M.
2005 Workshop:
mFISH Reveals an LET-Independent Excess of Radiation-Induced Dicentrics Involving Homologous Chromosomes
Plan, Y., Hlatky, L., Hahnfeldt, P., Sachs, R., Loucas, B., and Cornforth, M.
2003 Workshop:
Full 24-color Painting of Human Chromosomes Reveals Differences in the Spectra of Cytogenetic Damage Produced by 137Cs Y rays, 238Pu a Particles and 56Fe Ions
Cornforth, M.N. and Loucas, B.D.
2002 Workshop:
The Induction of Truly Simple Exchanges is not Independent of Dose Rate Loucas, B.D., Bailey, S.M., Goodwin, E.H., and Cornforth, M.N.
2001 Workshop:
Computer Simulations of Chromosome Aberration Data for Human Cells Subjected to Low-LET Radiation: Mechanistic Implications
Sachs, R., Cornforth, M.N., Vazquez, M., Arsuaga, J., Hlatky, L., Geard, C., and Brenner, D.
24-Color Cytogenetic Analysis of Human Cells Exposed to 137Cs g-Rays Delivered at High- Versus Low Dose Rates
Cornforth, M.N. and Loucas, B.D.
1999 Workshop:
Current Cytogenetic Issues Pertaining to Low Dose and Low Dose Rate Cornforth, M. and Loucas, B.
Publications
Bailey, S.M. and Cornforth, M.N. (2007) Telomeres and DNA double-strand breaks: Ever the twain shall meet? Cellular and Molecular Life Sciences 64(22):2956-2964.
Plan, Y., Hlatky, L., Hahnfeldt, P., Sachs, R., Loucas, B., and Cornforth, M. (2005) Full-color painting reveals an excess of radiation-induced dicentrics involving homologous chromosomes. International J. of Radiation Biology 81(8):613-620.
Vives, S., Loucas, B., Vazquez, M., Brenner, D.J., Sachs, R.K., Hlatky, L., Cornforth, M., and Arsuaga, J. (2005) SCHIP: statistics for chromosome interphase positioning based on interchange data. Application note. Bioinformatics 21(14):3181-3182.
Loucas, B.D. and Cornforth, M.N. (2004) Evidence that unrejoined DNA double-strand breaks are not predominantly responsible for chromosomal radiosensitivity of AT fibroblasts. Radiation Research 162:554-565.
Loucas, B.D., Eberle, R., Bailey, S.M., and Cornforth, M.N. (2004) Influence of dose rate on the induction of simple and complex chromosome exchanges by gamma rays. Radiation Research 162:339-349.
Zou, Y., Gryaznov, S.M., Shay, J.W., Wright, W.E., and Cornforth, M.N. (2004) Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. PNAS 101(35):12928-12933.
Bailey, S.M., Cornforth, M.N., Ullrich, R.L., and Goodwin, E.H. (2004) Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair 3:349-357.
Cornforth, M.N., Greulich-Bode, K.M., Loucas, B.D., Arsuaga, J., Vazequz, M., Sachs, R.K., Bruckner, M., Molls, M., Hahnfeldts, P. Hlatky, L., and Brenner, D.J. (2002) Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. of Cell Biology 159(2):237-244.
Cornforth, M.N., Bailey, S.M., and Goodwin, E.H. (2002) Dose response for chromosome aberrations produced in non-cycling primary human fibroblasts by alpha particles and by gamma rays delivered at sub-limiting low dose rates. Radiation Research 158:43-53.
Hlatky, L., Sachs, R.K., and Cornforth, M.N. (2002) Radiation-induced chromosome aberrations: Insights gained from biophysical modeling. BioEssays 24:714-723.
Bailey, S.M., Cornforth, M.N., Kurimasa, A., Chen, D.J., and Goodwin, E.H. (2001) Strand-specific postreplicative processing of mammalian telomeres. Science 293:2462-2465.
Cornforth, M.N. (2001) Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiation Research 155(5):643-659.
Loucas, B.D. and Cornforth, M.N. (2001) Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiation Research 155(5):660-671.
Sachs, R.K., Levy, D., Chen, A.M., Simpson, P.J., Cornforth, M.N., Ingerman, E.A., Hahnfeldt, P., and Hlatky, L.R. (2000) Random breakage and reunion chromosome aberration formation model: An interaction distance version based on chromatin geometry. International J. of Radiation Biology 76(12):1579-1588.
Ponnaiya, B., Cornforth, M.N., and Ullrich, R.L. (1997) Induction of chromosomal instability in human mammary cells by neutrons and gamma rays. Radiation Research 147:288-294.
Ponnaiya, B., Cornforth, M.N., and Ullrich, R.L. (1997) Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiation Research 147:121-125.
Tucker, J.D., Morgan, W.F., Awa, A.A., Bauchinger, M., Blakey, D., Cornforth, M.N., Littlefield, L.G., Natarajan, A.T., and Shasserre, C. (1995) A proposed system for scoring structural aberrations detected by chromosome painting. Cytogenet. Cell Genet. 68:211-221.
Cornforth, M.N. and Goodwin, E.H. (1991) The dose-dependent fragmentation of chromatin in human fibroblasts by 3.5-MeV a particles from 238Pu: Experimental and theoretical considerations pertaining to single-track effects. Radiation Research 127:64-74.
