Joel S. Bedford
Colorado State University
Newly Funded Project
Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability, abstract; description.
Currently Funded Projects
Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure; description.
Technical Abstracts
2006 Workshop
γH2AX Foci after Low Dose-Rate Irradiation Reveal a Defect in DNA DSB Processing in Cells from Unaffected Parents of Retinoblastoma Patients, ATM Heterozygotes, and Other Apparently Normal Humans
Kato, T.A., Nagasawa, H., Fitzek, M.M., Weil, M.M., Little, J. B., and Bedford, J.S.
Abnormal Gene Expression of Four Genes in Cells from Family Members of Hereditary-type Retinoblastoma Patients Relative to Normal Individuals.
Wang, C-Y., Peng, Y., Yang, Z., Li, C-Y., Nagasawa, H., Fitzek, M.M., Little, J.B., Bedford, J.S., Chuang, E.Y.
The Alpha-Particle Induced Bystander Effect for Sister Chromatid Exchanges in Fancg-Deficient CHO Cells
Nagasawa, H., Wilson, P.F., Thompson, L.H., Bedford, J.S., and Little, J.B.
2005 Workshop
Low Dose and Low Dose-Rate Irradiation for Identification of Individuals of High, Low and Intermediate Radiosensitivities Using the Gamma-H2AX Assay
Kato, T., Nagasawa, H., Weil, M., Genik, P., Peng, Y., Little, J.B., and Bedford, J.S.
2002 Workshop
Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure,
Bedford, J.S., Nagasawa, H., and Little, J.B. Department of Radiological Health Sciences, Colorado State University, Ft. Collins, CO Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA.
2001 Workshop:
NSCORT, Project 2: DNA Repair and Early Development of Chromosomal Changes,
Rydberg, B., Chernikova, S., and Cooper, P.K. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA. Bedford, J.S., Department of Radiological Health Sciences, Colorado State University, Fort Collins, CO.
On the Measurement of Radiation-Induced Chromosomal Instability in Normal Human Fibroblasts,
Dugan, L.C. and Bedford. J.S., Department of Radiological Health Sciences, Colorado State University, Fort Collins, CO.
Publications
Kato, T.A., Okayasu, R., and Bedford, J.S. (2008) Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells. Mutation Research 639(1-2):108-112.
Nagasawa, H., Wilson, P.E., Chen, D.J., Thompson, L.H., Bedford, J.S., and Little, J.B. (2008) Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. DNA Repair 7(3):515-522.
Wilson, P.E., Nagasawa, H., Warner, C.L., Fitzek, M.M., Little, J.B., and Bedford, J.S. (2008) Radiation sensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls: Colony formation ability during continuous low-dose-rate gamma irradiation. Radiation Research 169(5):483-494.
Chuang, E.Y., Chen, X., Tsai, M-H., Yan, H., Li, C-Y., Mitchell, J.B., Nagasawa, H., Wilson, P.F., Peng, Y., Fitzek, M.M., Bedford, J.S., and Little, J.B. (2006) Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. Cancer Research 66(7):3428-3433.
Hinz, J.M., Tebbs, R.S., Wilson, P.F., Nham,lowdose P.B., Saalazar, E.P., Nagasawa, H., Urbin, S.S., Bedford, J.S., and Thompson, L.H. (2006) Repression of mutagenesis by Rad51D-mediated homologous recombination. Nucleic Acids Research 34(5):1358-1368.
Kato, T.A., Nagasawa, H., Weil, M.M., Genik, P.C., Little, J.B., and Bedford, J.S. (2006) ?-H2AX foci after low-dose-rate irradiation reveal Atm haploinsufficiency in mice. Radiation Research 166(1):47-54.
Kato, T.A., Nagasawa, H., Weil, M.W., Little, J.B., and Bedford, J.S. (2006) Levels of ?-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two AT families and in another apparently normal individual. Radiation Research 166(3):443-453.
Yan, B., Wang, H., Peng, Y., Hu, Y., Wang, H., Zhang, X., Chen, Q., Bedford, J.S., Dewhirst, M.W., and Li, C. ( 2006) A unique role of the DNA fragmentation factor in maintaining genomic stability. PNAS 103(5):1504-1509.
Nagasawa, H., Peng, Y., Wilson, P.F., Lio, Y.-C., Chen, D.J., Bedford, J.S., and Little, J.B. (2005) Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiation Research 164:141-147.
Peng, Y., Woods, R.G., Beamish, H., Ye, R., Lees-Miller, S.P., Lavin, M.F., and Bedford, J.S. (2005) Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Research 65(5):1670-1677.
Hinton, T.G., Bedford, J.S., Congdon, J.C., and Whicker, F.W. (2004) Effects of radiation on the environment: A need to question old paradigms and enhance collaboration among radiation biologists and radiation ecologists. Radiation Research 162:332-338.
Bedford, J.S. (2003) Letters to the Editor Re: Target theory and Timofeeff-Ressovsky. Radiation Research 159:135.
Coleman, C.N., Stone, H.B., Alexander, G.A., Barcellos-Hoff, M.H., Bedford, J.S., Bristow, R.G., Dynlacht, J.R., Fuks, Z., Gorelic, L.S., Hill, R.P., Joiner, M.C., Liu, F.-F., McBride, W.H., Mckenna, W.G., Powell, S.N., Robbins, M.E.C., Rockwell, S., Schiff, P.B., Shaw, E.G., Siemann, D.W., Travis, E.L., Wallner, P.E., Wong, R.S.L., and Zeman, E.M. (2003) Education and training for radiation scientists: Radiation Research Program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003. Radiation Research 160:729-737
Dugan L.C. and Bedford, J.S. (2003) Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation? Radiation Research 159:301-311.
Takahashi, S., Hiroshi, S., Yoshihisa, K., Hiroshi, U., Bedford, J.S., and Ryuichi, O. (2002) Inhibition of DNA-double strand break repair by antimony compounds. Toxicology 180(3,2):249-256.
Peng, Y., Zhang, Q., Nagasawa, H., Okayasu, R., Liber, H.L., and Bedford, J.S. (2002) Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing and mutation. Cancer Research 62:6400-6404.
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