Edouard I. Azzam

UMDNJ- New Jersey Medical School

About the Project

Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts

Funded Projects

Cellular Responses to Low Dose/Very High Dose-rate Ionizing Radiation: The Role of Endogenous Oxidative Metabolism, abstract, description.

Technical Abstracts

2006 Workshops:

Adaptive Responses to Low Dose/Low Dose-Rate γ-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism
Azzam, E., de Toledo, S., Pandey, B.N., Venkatachalam, P., Buoannano, M., Yang, Z., Li, L., Gordon, D.M., Howell, R.W., Pain, D., and Spitz, D.R.

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation
Spitz, D.R., Dayal, D., Liu, A.T.Y., Slane, B., Aykin-Burns, N., Limoli, C.L., and Azzam, E.I.

2005 Workshops:

Ionizing Radiation Induced Adaptive Responses in Normal Human Cells Maintained in Three-Dimensional Architecture: The Role of Oxidative Metabolism
de Toledo, S.M., Asaad, N., Perumal, V., Li, L., Spitz, D.R., and Azzam, E.

Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts
Pandey, B.N., Gordon, D., Pain, D., and Azzam, E.

2003 Workshops:

Cellular Responses to Low Dose/Very Low Dose Rate Ionizing Radiation: The Role of Endogenous Oxidative Metabolism
de Toledo, S.M., Venkatachalam, P., Gardner, J.P., Li, L., Howell, R.W., Spitz, D.R., and Azzam, E.

The Role of Flavin Containing Oxidases in the Response of Normal Human Diploid Fibroblasts to Low Dose/Very Low Dose Rate γ-Radiation
Venkatachalam, P, de Toldeo, S.M., Howell, R.W., Spitz, D.R., and Azzam, E.

2001 Workshop

Transmission of Damage Signals from Irradiated to Non-irradiated Bystander Cells
Little, J.B., Azzam, E.I., Nagasawa, H., and de Toledo, S.M.

1999 Workshop

Effect of Low-Dose Alpha Irradiation in Human Cells: The Role of Induced Genes and the Bystander Effect
Nagasawa, H. and Azzam, E.I.

Publications

Venkatachalam, P., de Toledo, S., Pandey, B., Tephly, L.A., Carter, A.B., Little, J.B., Spitz, D.R., and Azzam, E.I. (2008). Regulation of normal cell cycle progression by flavin-containing oxidases. Oncogene 27(1):20-31.

Venkatachalam, P., de Toledo, S., Pandey, B., Tephly, L.A., Carter, A.B., Little, J.B., Spitz, D.R., and Azzam, E.I. (2008). Regulation of normal cell cycle progression by flavin-containing oxidases. Oncogene 27(1):20-31.

de Toledo, S. M., and Azzam E. I. (2006) Adaptive and bystander responses in human and rodent cell cultures exposed to low level ionizing radiation: The impact of linear energy transfer. Dose-Response 4(4):291-301.

de Toledo, S.M., Asaad, M., Venkatachalam, P., Li, L., Howell, R.W., Spitz, D.R., and Azzam, E.I.(2006). Adaptive response to low-dose/low-dose-rate γ rays in normal human fibroblast: The role of growth architecture and oxidative metabolism. Radiation Research 166:849-857.

Little, J.B., Azzam, E.I., de Toledo, S.M., and Nagasawa, H. (2005). Characteristics and mechanisms of the bystander response in monolayer cell cultures exposed to very low fluences to alpha particles. Radiation Physics and Chemistry 72:307-313.

Venkatachalam, P., de Toledo, S.M., and Azzam, E.I. (2005). Flavin-containing oxidases regulate progression from G 1 to S phase of the cell cycle in normal human diploid fibroblasts. Radiation Physics and Chemistry 72:315-321.

Azzam, E.I. and Little, J.B. (2004). The radiation-induced bystander effect: Evidence and significance. Human & Experimental Toxicology 23:61-65.

Spitz, D.R., Azzam, E.I., Li, J.J., and Gius, D. (2004). Metabolic oxidation/reduction reactions and cellular responses to radiation: A unifying concept in stress response biology. Cancer and Metastasis Reviews 23:311-322.

Azzam, E.I., Nagasawa, H., Yu, Y., Li, C.-Y., and Little, J.B. (2002). Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. The Society for Investigative Dermatology 119(6):1350-1354.

Azzam, E.I., de Toledo, S.M., Waker, A.J., and Little, J.B. (2000). High and low fluences of a-particles induce a G 1 checkpoint in human diploid fibroblasts. Cancer Research 60:2623-2631.

Dahlberg, W.K., Azzam, E.I., Yu, Y., and Little, J.B. (1999). Response of human tumor cells of varying radiosensitivity and radiocurability to fractionated irradiation. Cancer Research 59: 5365-5369.

Mitchel, R.E.J., Azzam, E.I., and DeToledo, S.M. (1997). Adaption to ionizing radiation in mammalian cells. In: Stress-inducible processes in higher eukaryotic cells, Kova (Ed.). New York: Plenum Press.

Azzam, E.I. , de Toldeo, S.M., and Little, B.J. (2004). Stress signaling from irradiated to non-irradiated cells. Current Cancer Drug Targets 4(1):53-64.

Azzam, E.I. (2004). Radiation induced adaptive and bystander effects in human and rodent cells exposed to low dose/fluence ionizing radiation. In: The 14th Pacific Basin Nuclear Conference, Honolulu, Hawaii.

Neti, P.V.S.V., de Toledo, S.M., Perumal, V., Azzam, E.I., and Howell, R.W. (2004). A multi-port low-fluence alpha-particle irradiator: Fabrication, testing and benchmark radiobiological studies. Radiation Research 161(6):732-738.

Azzam, E.I., de Toledo, S.M., and Little, J.B. (2003). Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22:7050-7057.

Mamon, H.J., Dahlberg, W., Azzam, E.I., Nagasawa, H., Muto, M.G. and Little, J.B. (2003). Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation. Radiation Biology 79(10):817-830.

Azzam, E.I., de Toledo, S.M., and Little, J.B. (2003). Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Research 63:7128-7135.

Little, J.B., Azzam, E.I., de Toledo, S.M., and Nagasawa, H. (2002). Bystander effects: Intercellular transmission of radiation damage signals. Radiation Protection Dosimetry 99(1-4):159-162.

Little, J.B., Nagasawa, H., de Toledo, S.M., and Azzam, E.I. (2002). Transmission of damge signals from irradiated to nonirradiated cells. International Congress Series 1236:229-235.

Azzam, E.I., de Toledo, S.M., Spitz, D.R., and Little, J.B. (2002). Oxidative metabolism modulates signal transduction and micronculeus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Research 62:5436-5442.

Azzam, E.I., de Toledo, S.M., Waker, A.J., and Little, J.B. (2000). High and low fluences of a-particles induce a G 1 checkpoint in human diploid fibroblasts. Cancer Research 60:2623-2631.

Azzam, E.I., de Toledo, S.M., Raaphorst, G.P., and Mitchel, R.E. (1996). Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiation Research 146(4):369-373.

Schöllnberger, H., Mitchel, R.E., Azzam, E.I., Crawford-Brown, D.J., and Hofmann, W. (2002). Explanation of protective effects of low doses of y-radiation with a mechanistic radiobiological model. International J. of Radiation Biology 78(12):1159-1173.

Azzam, E.I., de Toledo, S.M., and Little, J.B. (2001). Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from a-particle irradiated to nonirradiated cells. PNAS 98(2):473-478.

Azzam, E.I., de Toledo, S.M., Gooding, T., and Little, J.B (1998). Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research 150(5):497-504.

Azzam, E.I., Raaphorst, G.P., and Mitchel, R.E.J. (1994). Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in CsH 10T1/2 mouse embryo cells. Radiation Research 138(1 Suppl):S28-S31.

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