David A. Boothman
University of Texas, Southwestern Medical Center
Dallas, Texas
About this Project
The IGF-1/IGF-1R-MAPK-Secretory Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-Inducible Bystander effect
Currently Funded Project
Clusterin: A Low Dose IR-Inducible Molecular Switch Between Life and Death
Technical Abstracts
2006 Workshop:
Low dose ionizing radiation (IR) signaling regulation in vivo versus in vitro of the IFG-1/IGF-1R pathway leading to the synthesis of pro-survival secretory clusterin expression: Roles for p53/Hdm2.
Cataldo, E., Wilson, D., Sampath, L, Araki, S., Zou, Y., Shankar, B, Mayo, L., and Boothman, D.A.
2005 Workshop
Regulatory Mechanisms of Secretory Clusterin (sCLU) Expression: A Low Dose-inducible ‘Bystander’ Cytoprotective Protein.
Criswell, T., Cataldo, E., Araki, S., Leskov, K., Thakur, V., Sampath, L., Wilson, D., Mayo, L., and Boothman, D.A.
2003 Workshop
Bioluminescent Imaging of Clusterin (CLU) Transcriptional Activity After
Low Dose Ionizing Radiation: A Possible Approach in Biodosimetry.
Klokov, D., Sampath, L., Criswell, T., Wilson, D.L., and Boothman, D.A.
Secretory Clusterin (sCLU) Expression as a Sign of Genomic Instability and A Potential Promoter of Instability in Bystander Cells.
Criswell, T., Beman, M., Araki, S., Leskov, K., Klokov, D., and Boothman, D.A.
2002 Workshop
Synthesis of Pro-Apoptotic Forms of Clusterin: An Ionizing Radiation-Induced Protein.
Leskov, K.S., Li, J., Klokov, D.V., and Boothmam, D.A.
Transcriptional Repression of Clusterin by the p53 Tumor Suppressor Protein.
Criswell, T., Klekov, D., Lavik, J.P., Isreal, S.,
Leskov, K., and Boothman, D.A.
2001 Workshop
Clusterin -- A Novel p53 Repressed Secretory Protein
Criswell, T., Yangland, C.R., and Boothman, D.A.
Structure-Functional Analysis of Clusterin: Ku70 Association and Cell Death.
Leskov, K.S., Kinsella, T.J., and Boothman, D.A.
1999 Workshop
Nuclear apoJ/XIP8: A Cell Death Signal Regulated By p53 Induction Responses.
Boothman, D.A. and Aronow, B.
Publications
Suzuki, M. and Boothman, D.A. (2008) Stress-induced premature senescence (SIPS). Journal of Radiation Research 49(2):105-112.
Choi, E.K., Terai, K., Ji, I.-M., Kook, Y.H., Park, K.H., Oh, E.T., Griffin, R.J., Lim, B.U., Kim, J.S., Lee, D.S., Boothman, D.A., Loren, M., Song, C.W., and Park, H.J. (2007). Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive [beta]-lapachone on cancer cells. Neoplasia 9(8):634-642.
Shannan, B., Seifert, M., Boothman, D.A., Tilgen, W., and Reichrath, J. (2007). Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)2D3 in prostate cancer cells In vitro. Journal of Steroid Biochemistry and Molecular Biology 103(3-5):721-725.
Blanco, E., Bey, E.A., Dong, Y., Weinberg, B.D., Sutton, D.M., Boothman, D.A., and Gao, J. (2007). beta-Lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. Journal of Controlled Release 122(3):365-374.
Shannan, B., Seifert, M., Leskov, K., Willis, J., Boothman, D.A., Tilgen, W., and Reichrath, J. (2006). Challenge and promise: Roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death and Differentiation 13:12-19.
Araki, S., Israel, S., Leskov., K.S., Criswell, T.L., Beman, M., Klokov, D.Y., Sampalth, L., Reinicke, K.E., Cataldo, E., Mayo, L.D., and Boothman, D.A. (2005). Clusterin proteins: Stress-inducible polypeptides with proposed functions in multiple organ dysfunction. British Institute of Radiology Supplement 27:106-113.
Criswell, T., Beman, M., Araki, S., Leskov, K., Cataldo, E., Mayo, L., and Boothman, D.A. (2005). Delayed activation of IGF-1RSrc/MAPK signaling after IR regulates clusterin expression, a pro-survival protein. Journal of Biological Chemistry 280(14):14212-14221.
Park, H.J., Ahn, K., Ahn, S., Choi, E., Lee, S.W., Williams, B., Kim, E.J., Griffin, R., Bey, E.A., Bornmann, W.G., Gao, J., Park, H.J., Boothman, D.A., and Song, C.W. (2005). Susceptibility of cancer cells to ß - lapachone is enhanced by ionizing radiation. International Journal Radiation Oncology Biology Physics 61(1):212-219.
Meyers, M., Hwang, A., Wagner, M.W., and Boothman, D.A. (2004). Special section: Impact of the environment on colon cancer (II). Environmental and Molecular Mutagenesis 44:249-264.
Klokov, D., Criswell, T., Leskov, K.S., Araki, S., Mayo, L., and Boothman, D.A. (2004). IR-inducible clusterin gene expression: A protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects. Mutation Research 568(1):97-110.
Klokov, D., Criswell, T., Sampath, L., Leskov, K.S., Frinkley, K., Araki, S., Beman, M., Wilson, D.L., and Boothman, D.A. (2003). Clusterin: A protein with multiple functions as a potential ionizing radiation exposure marker. International Congress Series 1258:219-232.
Criswell, T., Klokov, K.S., and Boothman, D.A. (2003). IR-inducible transcriptional repression of clusterin by the p53 tumor suppressor protein. Cancer Biology and Therapy 2(4):25-31.
Criswell, T., Klokov, K.S., and Boothman, D.A. (2003). Transcriptional repression of clusterin by the p53 tumor suppressor protein. Cancer Biology and Therapy 2(4):25-31.
Sun, W., Sawada, M., Hayes, P., Leskov, K., Boothman, D.A., and Matsuyama, S. (2003). Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nature Cell Biology 5:320-329
Leskov, K.S., Klokov, D.Y., Li, J., Yang, C.R., Kinsella, T.J., and Boothman, D.A. (2003). Synthesis and functional analyses of nuclear clusterin, a cell death protein. Journal of Biological Chemistry 278(13):11590-11600.
Criswell, T., Leskov, K., Miyamoto, S., Luo, G., and Boothman, D.A. (2003). Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22(37):5813-5827.
Leskov, K., Antonio, S., Criswell, T., Yang, C.-R., Kinella, T.J., and Boothman, D.A. (2001). Radiation-inducible clusterin (CLU): A molecular switch between life and death. Radiation Research 156(4):441-442.
Leskov, K., Criswell, T.A., Antonio, S., Li, J., Yang, C.-R., Kinsella, T.J., and Boothman, D.A. (2001). When X-ray-inducible proteins meet DNA double strand break repair. Seminars in Radiation Oncology 11(4):352-372.
Yan, T., Schupp, J.E., Hwang, H.S., Wagner, M.W., Berry, S.E., Strickfaden, S., Veigl, M.L., Sedwick, W.D., Boothman, D.A., and Kinsella, T.J. (2001). Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation. Cancer Research 61(22):8290-8297.
Huang, T.T., Wuerzberger-Davis, S.M., Seufzer, B.J., Shumway, S.D., Kurama, T., Boothman, D.A., and Miyamoto, S. (2000). NF- kB activation by Camptothecin: A linkage between nuclear DNA damage and cytoplasmic signaling events. Journal of Biological Chemistry 275(13):9501-9509.
Yang, C.R., Wilson-Van Patten, C., Planchon, S.M., Wuerzberger-Davis, S.M., Davis, T.W., Cuthill, S., Miyamoto, S., and Boothman, D.A. (2000). Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation. Journal of the Federatin of American Societies for Experimental Biology 14(2):379-390.
Yang, C.-R., Odegaard, E., Leskov, K., Hosley-Eberlein, K., Criswell, T., Kinsella, T.J., and Boothman, D.A. (2000). Nuclear clusterin/XIP8, an X-ray induced KU70-binding protein that signals cell death. Proceedings of the National Academy of Sciences of the United States of America 97:5907-5912.
Kalka, K., Ahmad, N., Criswell, T., Boothman, D.A., and Mukhtar, H. (2000). Upregulation of clusterin during photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Cancer Research 60(21):5984-5987.
Yang, C.-R., Odegaard, E., Leskov, K., Hosley-Eberlein, K., Criswell, T., Kinsella, T.J., and Boothman, D.A. (2000). Nuclear clusterin/XIP8, an X-ray-induced Ku70-binding protein that signals cell death. Proceedings of the National Academy of Sciences of the United States of America 97(11):5907-5912.
Yang, C.-Y., Leskov, K., Hosley-Eberlein, K.J., Criswell, T.L., Mooney, M.A., Pink, J.J., and Boothman, D.A. (2000). Ku70-binding proteins. In: Radiation Research. 11th International Congress of Radiation Research, Dublin, Ireland, July 18-23, 1999. M. Moriarty, C. Mothersill, C. Seymore, M. Edington, J.F. Ward, and R.J.M. Fry (Eds.) International Association for Radiation Research 2:426-429.
Badie, B., Goh, C.S., Klaver, J., Herweijer, H., and Boothman, D.A. (1999). Combined radiation and p53 gene therapy of malignant glioma cells. Cancer Gene Therapy 6:155-162.
Yang, C.R., Yeh, S.Y., Leskov, K., Odegaard, E., Hsu, H.L., Chang, C., Kinsella, T.J., Chen, D.J., and Boothman, D.A. (1999). Isolation of Ku70-binding proteins (KUBs). Nucleic Acids Research 27(10):2165-2174.
Mendonca, M.S., Howard, K.L., Farrington, D.L., Desmond, L.A., Temples, T.M., Mayhugh, B.M., Pink, J.J., and Boothman, D.A. (1999). Delayed apoptotic responses associated with radiation-induced neoplastic transformation of human hybrid cells. Cancer Research 59(16):3972-3979.
Odegaard, E., Yang, C.R., and Boothman, D.A. (1998). DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation. Environmental Health Perspectives 106:301-305
Limoli, C.L., Hartmann, A., Shepard, L., Yang, C.R., Boothman, D.A., Bartholomew, J., and Morgan, W.F. (1998). Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer Research 58:(16):3712-3718.
Boothman, D.A., Odegaard, E., Yang, C.-R., Hosley, K., and Mendonca, M. (1998). Molecular analyses of adaptive survival responses (ASRs): Role of ASRs in radiotherapy. Human and Experimental Toxicology 17:448-453.
Davis, T.W., Meyers, M., Wilson-Van Patten, C., Sharda, N., Yang, C.R., Kinsella, T.J., and Boothman, D.A. (1998). Transcriptional responses to damage created by ionizing radiation: Molecular sensors. In: DNA Damage and repair, Vol. 2: DNA repair in higher eukaryotes. J.A. Nickoloff and M.F. Hoekstra (Ed.). Totowa, New Jersey : Humana Press, pp. 223-262.
Boothman, D.A., Meyers, M., Odegaard, E., and Wang, M. (1996). Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation. Mutation Research 358:143-153.
Sahijjak, W.M., Yang, C.R., Zuckerman, J.S., Meyers, M., and Boothman, D.A. (1994). Alterations in transcription factor binding in radioresistant human melanoma cells after ionizing radiation. Radiation Research 138(1): S47-S51.
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