Allan Balmain
University of California, San Francisco
About This Project
Fbxw7/Cdc4 is a p53-Dependent Haploinsufficient Tumour Suppressor Gene
Funded Projects
Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis, abstract, description.
An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue, abstract, description.
Technical Abstracts
2006 Workshops:
Genomic Signatures for Radiation-Induced Mouse Lymphoma
Mao, J-H., Li, J., Jiang, T., Li. Q., Wu, D., Perez-Losada, J., DelRosario, R., Peterson, L., Cai, W-W., and Balmain, A.
2005 Workshops:
Fbxw7/Cdc4 is a p53-Dependent Haploinsufficient Tumour Suppressor Gene
Mao, J.H., Perez-losada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K., Brown, K., Bryson, S., and Balmain, A.
Publications
Mao, J.H., Wu, D., DelRosario, R., Castellanos, A., Balmain, A., and Perez-Losada, J. (2008) ATM heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background. Oncogene 27(51):6596-6600.
Chiaverotti, T., Couto, S.S., Donjacour, A., Mao, J.H., Nagase, H., Cardiff, R.D., Cunha, G.R., and Balmain, A. (2008) Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. American J. of Pathology 172(1):236-246.
Wakabayashi, Y., Mao, J.H., Brown, K., Girardi, M., and Balmain, A. (2007) Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature 445(7129):761-765.
Wei, G.W., Ku, S., Ma, G.K., Saito, S., Tang, A.A., Zhang, J., Mao, J.H., Appella, E., Balmain, A., and Huang, E.J. (2007) HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. PNAS 104(32):13040-13045.
Ewart-Toland, A., Dai, Q., Gao, Y.-T., Nagase, H., Dunlop, M.G., Farrington, S.M., Barnetson, R.A., Anton-Culver, H., Peel, D., Ziogas, A., Lin, D., Miao, X., Sun, T., Ostrander, E.A., Stanford, J.L., Langlois, M., Chan, J.M., Yuan, J., Harris, C.C., Bowman, E.D., Clayman, G.L., Lippman, S.M., Lee, J.J., Zheng, W., and Balmain A. (2005) Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: A meta-analysis of multiple cancer types. Carcinogenesis 26(8):1368-1373.
Mao, J., Li, J., Jiang, T., Li, Q., Wu, D., Perez-Losada, J., DelRosario, R., Peterson, L., Balmain, A. and Cai, W. (2005) Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene 24:7924-7934.
Perez-Losada, J., Mao, J.-H., and Balmain, A. (2005) Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Research 65:6488-6492.
Perez-Losada, J., Wu, D., DelRosario, R., Balmain, A., and Mao, J.-H. (2005) p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene 24:5521-5524.
Balmain, A. and Akhurst, R.J. (2004) Dangerous liaisons. Nature 428:271-272.
Ewart-Toland, A., Chan, J.M., Yuan, J., Balmain, A., and Ma, J. (2004) A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiology Biomarkers & Prevention 13:759-764.
Mao, J.-H. and Balmain, A. (2003) Genomic approaches to identification of tumor-susceptibility genes using mouse models. Current Opinion in Genetics & Development 13:14-19.
Mao, J.-H., Wu, D., Perez-Losada, J., Nagese, H., DelRosario, R., and Balmain, A. (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene 22:8379-8385.
Ewart-Toland, A., Briassouli, P., de Koning, J.P., Mao, J.-H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B.A.J., Nagese, H., Burn, J., Ball, S., Almeida, M., Linardopoulos, S., and Balmain, A. (2003) Identification of Stk6/sTK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nature Genetics 34(4):403-412.
Mao, J.-H., Wu, D., Perez-Losada, J., Nagase, H., DelRosario, R., and Balmain, A. (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene 22:8379-8385.
Derynck, R., Akhurst, R.J., and Balmain, A. (2001) TGF-beta signaling in tumor suppression and cancer progression. Nature Genetics 29:117-129.
Balmain, A. and Nagase, H. (1998) Cancer resistance genes in mice: Models for the study of tumour modifiers. TIG 14(4):139-144.
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