Francis Cucinotta

National Aeronautics and Space Administration

Newly Funded Projects

Radiation Sensitvity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair-Deficient Cells.

Technical Abstracts

2006 Workshop
Stochastic Models of Space Radiation DNA Damage Responses and Cancer Risks.
Cucinotta, F.A., Pluth, J.M., Ponomarev, A., Hu, S., Anderson, J., Harper, J., O'Neill, P.

Publications

Cucinotta, F.A. (2008). Systems biology and understanding radiation sensitivity of astronauts. Radiation Research 170(5):674-675.

Cucinotta, F.A., Kim, M.H.Y., Willingham, V., and George, K.A. (2008) Physical and biological organ dosimetry analysis for international space station astronauts. Radiation Research 170(1):127-138.

Costes, S.V., Ponomarev, A., Chen, J.L., Nguyen, D., Cucinotta, F.A., and Barcellos-Hoff, M.H. (2007). Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLOS Computational Biology 3(8):1477-1488.

Ponomarev, A.L., Belli, M., Hahnfeldt, P.J., Hlatky, L., Sachs, R.K., and Cucinotta, F.A. (2007) Subtraction of background damage in PFGE experiments on DNA fragment-size distributions. Radiation and Environmental Biophysics. 46(2):155-160.

Kan'o, M., Kawata, T., Ito, H., Shigematsu, N., Liu, C., Uno, T., Isobe, K., Kawakami, H., Cucinotta, F.A., George, K., and Kubo, A. (2007). Repair of potentially lethal damage in normal cells and Ataxia Telangiectasia cells: Consideration of non-homologous end-joining. Journal of Radiation Research 48(1):31-38.

Kim, M.-H.Y. and Cucinotta, F.A. (2007). A temporal forecast of radiation environments for future space exploration missions. Radiation and Environmental and Biophysics. 46:95-100.

Nikjoo, H., Uehara, S., Pinsky, L., and Cucinotta, F.A. (2007). Modelling and calculations of the response of tissue equivalent proportional counter to charged particles. Radiation Protection and Dosimetry 126(1-4):512-518.

Cucinotta, F.A. and Durante, M. (2006). Cancer risk from exposure to galactic cosmic rays: Implications for space exploration by human beings. Lancet Oncology 7(5):431-435.

Durante, M., George, K., and Cucinotta, F.A. (2006). Chromosomes lacking telomeres are present in the progeny of human lymphocytes exposed to heavy ions. Radiation Research 165:51-58.

Ponomarev, A.L. and Cucinotta, F.A. (2006). Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes. International Journal of Radiation Biology 82(4):293-305.

Ponomarev, A.L., Belli, M., Hahnfeldt, J., P., Hlatky, L., Sachs, R.K., Cucinotta, F.A. (2006). A robust procedure for removing background damage in assays of radiation-induced DNA fragment distribution. Radiation Research 166:908-916.

Wu, H., Hada, M., Meador, J., Hu. X., Rusek, A., and Cucinotta, F. A. (2006). Induction of micronuclei in human fibroblasts across the bragg curve of energetic heavy ions. Radiation Research 166:583-589

Cucinotta, F.A., Schimmerling, W., Wilson, J.W., Peterson, L.E., Safanti, P.B., and Dicello, J.F.(2004). Uncertainties in estimates of the risks of late effects from space radiation. Advances in Space Research 34(6):1383-1389.

Durante, M., George, K., Wu, H., and Cucinotta, F.A. (2002). Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiation Research 158(5):581-590.

Cucinotta, F.A., Schimmerling, W., Wilson, J.W., Peterson, L.E., Badhwar, G.D., Saganti, P.B., and Dicello, J.F. (2001). Space radiation cancer risks and uncertainties for Mars missions. Radiation Research 156(5):682-688.

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